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CSA Names: AM678
CSA Location: Schedule I Section (g) Subsection (3) DEA code 7118
CSA History: S. 3187, 112 Cong., 2nd Sess. added effective 9 Jul 2012
78 FR 664 finalized the prior interim scheduling effective 4 Jan 2013
Names: JWH-018 (primary)
Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone (IUPAC)
Molecular formula: C24H23NO
Nominal mass: 341
Average mass: 341.4455
Monoisotopic mass: 341.177964
CAS registry number: 209414-07-3
ChemSpider: 8558143
PubChem: 10382701
Wikipedia: JWH-018
Erowid: Spice Product
Drugs-Forum: JWH-018
Bluelight: JWH-018
Standard InChI: InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
SMILES: CCCCCn1cc(c2c1cccc2)C(=O)c1cccc2c1cccc2
Tags: USCSA,cannabinoid,S.3187
Property Value Remarks
Property Value Remarks
Location Type Remarks
JWH-018 IR.pdf ATR IR
JWH-018 MS.pdf EI MS RTI
10697-0425868-GCMS.pdf EI MS 6-methoxyindole analog
10690-0428073-GCMS.pdf EI MS 2-methylbutyl isomer
11047-0434100-GCMS.pdf EI MS 5-bromopentyl analog
9000799-0434633-GCMS.pdf EI MS adamantyl analog
9001000-0432909-GCMS.pdf EI MS 1,1-dimethylpropyl isomer
9001007-0434491-GCMS.pdf EI MS 2'-naphthyl-N-1,1-dimethylpropyl isomer
9001003-0429805-GCMS.pdf EI MS 1,2-dimethylpropyl isomer
11585-0437006-GCMS.pdf EI MS 1-ethylpropyl isomer
11586-0437007-GCMS.pdf EI MS 2'-naphthyl-N-(1-ethylpropyl) isomer
9001006-0429792-GCMS.pdf EI MS 2'-naphthyl-N-(1,2-dimethylpropyl) isomer
11075-0432197-GCMS.pdf EI MS 4,5-epoxypentyl analog
13169-0435196-GCMS.pdf EI MS Agilent 5973 MSD
JWH-018.pdf EI MS Agilent 5975 MSD
10691-0427677-GCMS.pdf EI MS 3-methylbutyl isomer
10521-0434099-GCMS.pdf EI MS 5-chloropentyl analog
9001001-0429775-GCMS.pdf EI MS 2,2-dimethylpropyl isomer
9001002-0429776-GCMS.pdf EI MS 1-methylbutyl isomer
9001004-0429777-GCMS.pdf EI MS 2'-naphthyl isomer
9001005-0429779-GCMS.pdf EI MS 2'-naphthyl-N-3-methylbutyl isomer
9001008-0429780-GCMS.pdf EI MS 2'-naphthyl-N-2,2-dimethylpropyl isomer
9001009-0429781-GCMS.pdf EI MS 2'-naphthyl-N-1-methylbutyl isomer
9001010-0429782-GCMS.pdf EI MS 2'-naphthyl-N-2-methylbutyl isomer
JWH018 IRD.pdf GC IRD gas phase
JWH 018 N-(1-methylbutyl) isomer IR.pdf SP-GC-IR N-(1-methylbutyl) isomer (solid phase IR)
JWH 018 N-(2,2-dimethylpropyl) isomer IR.pdf SP-GC-IR N-(2,2-dimethylpropyl) isomer (solid phase IR)
JWH 018 N-(2-methybutyl) isomer.pdf SP-GC-IR N-(2-methylbutyl) isomer (solid phase IR)
JWH 018 N-(3-methylbutyl) isomer.pdf SP-GC-IR N-(3-methylbutyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(1-ethylpropyl) isomer.pdf SP-GC-IR 2'-naphthyl-N-(1-ethylpropyl) isomer (solid phase IR)
JWH-018 CCCC No. 10900.pdf SP-GC-IR Solid Phase IR
JWH 018 N-(1-ethylpropyl) isomer IR.pdf SP-GC-IR N-(1-ethylpropyl) isomer (solid phase IR)
JWH 018 N-(1,2-dimethylpropyl) isomer IR.pdf SP-GC-IR N-(1,2-dimethylpropyl) isomer (solid phase IR)
JWH 018 N-(1,1-dimethylpropyl) isomer IR.pdf SP-GC-IR N-(1,1-dimethylpropyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(2-methylbutyl) isomer IR.pdf SP-GC-IR 2'-naphthyl-N-(2-methylbutyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(2,2-dimethylpropyl) isomer IR.pdf SP-GC-IR 2'-naphthyl-N-(2,2-dimethylpropyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(1-methylbutyl) isomerIR.pdf SP-GC-IR 2'-naphthyl-N-(1-methylbutyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(1,2-dimethylpropyl) isomer IR.pdf SP-GC-IR 2'-naphthyl-N-(1,2-dimethylproplyl) isomer (solid phase IR)
JWH 018 2-naphthyl-N-(1,1-dimethylpropyl) isomer.pdf SP-GC-IR 2'-naphthyl-N-(1,1-dimethylpropyl) isomer (solid phase IR)
JWH 018 2-naphthyl isomer IR.pdf SP-GC-IR 2'-naphthyl isomer (solid phase IR)
JWH 018 2-naphthyl-N-(3-methylbutyl) isomer IR.pdf SP-GC-IR 2'-naphthyl-N-(3-methylbutyl) isomer (solid phase IR)
Vendor ID URL
Biosynth Q-200132
Cayman Chemical 10697 (6-methoxyindole analog)
Cayman Chemical 9001005 (2'-naphthyl-N-3-methylbutyl isomer)
Cayman Chemical 9001007 (2'-naphtyhl-N-(1,1-dimethylpropyl) isomer)
Cayman Chemical 10900
Cayman Chemical 9001001 (2,2-dimethylpropyl isomer)
Cayman Chemical 10690 (2-methylbutyl isomer)
Cayman Chemical 9001008 (2'-naphthyl-N-2,2-dimethylpropyl isomer)
Cayman Chemical 9001006 (2'-naphthyl-N-(1,2-dimethylpropyl) isomer)
Cayman Chemical 11075 (4,5-epoxypentyl analog)
Cayman Chemical 9001002 (1-methylbutyl isomer)
Cayman Chemical 11047 (5-bromopentyl analog)
Cayman Chemical 9001009 (2'-naphthyl-N-1-methylbutyl isomer)
Cayman Chemical 10691 (3-methylbutyl isomer)
Cayman Chemical 13169 (DEA exempt formulation)
Cayman Chemical 11047 (5-bromopentyl analog)
Cayman Chemical 9001004 (2'-naphthyl isomer)
Cayman Chemical 9001000 (1,1-dimethylpropyl isomer)
Cayman Chemical 9001010 (2'-naphthyl-N-2-methylbutyl isomer)
Cayman Chemical 10521 (5-chloropentyl analog)
Cerilliant S-025
Lipomed JWH-1294
THC Pharm JWH-018
Tocris Bioscience 1342
Toronto Research Chemicals P283650
Title Publication Date Vol. Iss. Page(s) Remarks
A new pyrazole-carboxamide type synthetic cannabinoid AB-CHFUPYCA [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide] identified in illegal product Forensic Toxicology 2015-07-01 Vol 33 (367-373) Nahoko Uchiyama et al
Consideration of the major cannabinoid agonists 2009-07-00 Advisory Council on the Misuse of Drugs
Understanding the Spice phenomenon 2009-00-00 European Monitoring Centre for Drugs and Drug Addiction
Further consideration of the synthetic cannabinoids 2012-10-18 Advisory Council on the Misuse of Drugs
GC–MS and FTIR evaluation of the six benzoyl-substituted-1-pentylindoles: Isomeric synthetic cannabinoids Talanta 2014-11-01 Vol 129 (171-182) Forrest T. Smitha et al
Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary Forensic Science International 2012-01-01 Vol 214 (27-32) Péter Jankovics et al
Synthetic cannabinoids and cathinones: prevalence and markets Forensic Science Review 2013-03-01 Vol 25 (7-26) Bretteville-Jensen et al
Identification and analytical properties of new synthetic cannabimimetics bearing 2,2,3,3-tetramethylcyclopropanecarbonyl moiety Forensic Science International 2013-03-10 Vol 226 (62-73) Vadim Shevyrin et al
Spice, bath salts, and the U.S. military: the emergence of synthetic cannabinoid receptor agonists and cathinones in the U.S. Armed Forces. 2012-09-01 Loeffler G, Hurst D, Penn A, Yung K
Synthetic cannabinoid and marijuana exposures reported to poison centers Hum Exp Toxicol 2012-10-31 (1006-1011) MB Forrester et al
Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC–MS, NMR analysis and a flash chromato Forensic Science International 2012-07-12 Vol 220 (e17-e22) Bjoern Moosmann et al
Cannabinoid chemistry: an overview Cannabinoids as Therapeutics 2005-01-01 (23-46) Lumír O. Hanuš and Raphael Mechoulam
- SCHEDULING UPDATE - [Synthetic Cannabinoids] Microgram Bulletin 2011-01-00 Vol 44 (1) Proposed Temporary Placement of Five Synthetic Cannabinoids Into Schedule I
Analytical Profile of Two Synthetic Cannabinoids-JWH-018 and JWH-073 (Law Enforcement Restricted Publication) Journal of CLIC 2010-04-00 Vol 20 (2) Law Enforcement Restricted
Quantitative Detection of the Active Blutalkohol 2009-00-00 Vol 46 Neukamm et al.
Synthetic Cannabinoids in Various Smoking Blends and Herbal Incense Products Journal of CLIC 2011-04-00 Vol 21 (2) Law Enforcement Restricted
Synthetic Cannabinoid Isomer Differentiation Journal of CLIC 2011-10-00 Vol 21 (4) Law Enforcement Restricted
Identification of a Cannabimimetic Indole as a Designer Drug in a Herbal Product Forensic Toxicol. 2009-00-00 Vol 27 Uchiyama et al
Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography–tandem mass spectrometry J. Chromatography B 2010-10-01 Vol 878 (27) Teske et al.
Chemical Analysis of Synthetic Cannabinoids as Designer Drugs in Herbal Products For. Sci. Int. 2010-00-00 Vol 198 Uchiyama et al.
Use of High-Resolution Accurate Mass Spectrometry to Detect Reported and Previously Unreported Cannabinomimetics in J. Anal. Toxicol. 2010-06-00 Vol 34 Hudson et al.
JMS Letter: J. Mass Spectrom. 2009-00-00 Vol 44 Auwarter et al.
Comprehensive review of the detection methods for synthetic cannabinoids and cathinones Forensic Toxicology 2015-07-01 Vol 33 (175-194) Akira Namera et al
The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse ACS Chem. Neurosci 2013-00-00 Vol 4 (1081–1092) Samuel D. Banister et al
JWH-018 and JWH-022 as Combustion Products of AM2201 Microgram Journal 2012-00-00 Vol 9 (2) Kathryn M. Donohue and Robert R. Steiner
Analysis of Synthetic Cannabinoids from Urine for Forensic Toxicology using Oasis HLB μElution plates and CORTECS UPLC Columns. 2013-01-01 J. P. Danaceau, E. E. Chambers, and K. J. Fountain
Phenazepam and cannabinomimetics sold as herbal highs in New Zealand Drug Testing and Analysis 2012-06-01 Vol 4 (6) R. A. F. Couch and H. Madhavaram
Identification, extraction and quantification of the synthetic cannabinoid JWH-018 from commercially available herbal marijuana alternatives For. Sci. Int. 2012-11-30 Vol 223 Sage J.B. Dunham, Paul D. Hooker, Robyn M. Hyde
Synthetic cannabinoids in “spice-like” herbal blends: First appearance of JWH-307 and recurrence of JWH-018 on the German market For. Sci. Int. 2012-10-10 Vol 222 Ludger Ernst et al
Identification of Synthetic Cannabinoids in Herbal Incense Blends in the United States J. For. Sci. 2012-09-01 Vol 57 Barry K. Logan et al
Determination of the chemical composition of Spice aromatic smoking blends by chromatography-mass spectrometry J. Analytical Chem. 2011-12-01 Vol 66 (12) S. V. Nekhoroshev, V. P. Nekhoroshev, M. N. Remizova, A. V. Nekhorosheva
Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism Journal of Mass Spectrometry 2013-07-01 Vol 48 (885-894) Melanie Hutter et al
Identification of 1-butyl-3-(1-(4-methyl)naphtoyl)indole detected for the first time in “herbal high” products on the Italian market Forensic Science International 2012-11-30 Vol 223 (e42-e46) Ermanno Valoti et al
Rapid identification of synthetic cannabinoids in herbal samples via direct analysis in real time mass spectrometry Rapid Comm. in Mass Spec 2012-05-15 Vol 26 (1109-1114) Rabi A. Musah et al
1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice Drug and Alcohol Dependence 2011-11-01 Vol 123 (148-153) Jenny L. Wileyet al
The emergence and analysis of synthetic cannabinoids Drug Testing and Analysis 2011-08-01 Vol 3 (466-478) Simon Hudson and John Ramsey
Database ID URL
SWGDRUG Mass Spectral Library 536
Mass Spectra of Designer Drugs 2010
SWGDRUG Monographs JWH-018 Monograph
Cayman Spectral Database
Society of Forensic Toxicologists Designer Drug Monographs JWH-018 Monograph
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