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CSA Names: JWH-081
CSA Location: Schedule I Section (g) Subsection (8) DEA code 7081
CSA History: S. 3187, 112 Cong., 2nd Sess. added effective 9 Jul 2012
78 FR 664 finalized the prior interim scheduling effective 4 Jan 2013
Names: JWH-081 (primary)
(4-Methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone (IUPAC)
Molecular formula: C25H25NO2
Nominal mass: 371
Average mass: 371.4715
Monoisotopic mass: 371.188529
CAS registry number: 210179-46-7
ChemSpider: 8722599
PubChem: 10547208
Wikipedia: JWH-081
Standard InChI: InChI=1S/C25H25NO2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17H,3-4,9,16H2,1-2H3
SMILES: CCCCCn1cc(c2c1cccc2)C(=O)c1ccc(c2c1cccc2)OC
Tags: cannabinoid,S.3187,USCSA
Property Value Remarks
Property Value Remarks
Location Type Remarks
JWH 081 ATRIR.pdf ATR IR Themo Nicolet
JWH-081 MS.pdf EI MS Agilent 5975 MS
9001045-0431272-GCMS.pdf EI MS 3-methoxynaphthyl isomer
9001049-0431276-GCMS.pdf EI MS 8-methoxynaphthyl isomer
9001047-0431274-GCMS.pdf EI MS 6-methoxynaphthyl isomer
9001046-0431273-GCMS.pdf EI MS 5-methoxynaphthyl isomer
9001048-0431275-GCMS.pdf EI MS 7-methoxynaphthyl isomer
9001044-0431076-GCMS.pdf EI MS 2-methoxynaphthyl isomer
10579-0423966-GCMS.pdf EI MS Agilent 5973 MSD
JWH 081 8-methoxynaphthyl isomer.pdf SP-GC-IR 8-methoxynaphthyl isomer (solid phase IR)
JWH 081 7-methoxynaphthyl isomer.pdf SP-GC-IR 7-methoxynaphthyl isomer (solid phase IR)
JWH 081 6-methoxynaphthyl isomer.pdf SP-GC-IR 6-methoxynaphthyl isomer (solid phase IR)
JWH 081 5-methoxynaphthyl isomer.pdf SP-GC-IR 5-methoxynaphthyl isomer (solid phase IR)
JWH 081 3-methoxynaphthyl isomer.pdf SP-GC-IR 3-methoxynaphthyl isomer (solid phase IR)
JWH 081 2-methoxynaphthyl isomer.pdf SP-GC-IR 2-methoxynaphthyl isomer (solid phase IR)
JWH-081 CCCC No. 10579.pdf SP-GC-IR Solid Phase IR
Vendor ID URL
Cayman Chemical 9001045 (3-methoxynaphthyl isomer)
Cayman Chemical 13636
Cayman Chemical 9001048 (7-methoxynaphthyl isomer)
Cayman Chemical 9001046 (5-methoxynaphthyl isomer)
Cayman Chemical 9001047 (6-methoxynaphthyl isomer)
Cayman Chemical 9001044 (2-methoxynaphthyl isomer)
LGC THC-1272-100
Lipomed JWH-1505§ion=mediadir&cmd=detail
THC Pharm THC-1272
Toronto Research Chemicals P283600
Title Publication Date Vol. Iss. Page(s) Remarks
A new pyrazole-carboxamide type synthetic cannabinoid AB-CHFUPYCA [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide] identified in illegal product Forensic Toxicology 2015-07-01 Vol 33 (367-373) Nahoko Uchiyama et al
Consideration of the major cannabinoid agonists 2009-07-00 Advisory Council on the Misuse of Drugs
Understanding the Spice phenomenon 2009-00-00 European Monitoring Centre for Drugs and Drug Addiction
Further consideration of the synthetic cannabinoids 2012-10-18 Advisory Council on the Misuse of Drugs
GC–MS and FTIR evaluation of the six benzoyl-substituted-1-pentylindoles: Isomeric synthetic cannabinoids Talanta 2014-11-01 Vol 129 (171-182) Forrest T. Smitha et al
Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary Forensic Science International 2012-01-01 Vol 214 (27-32) Péter Jankovics et al
Synthetic cannabinoids and cathinones: prevalence and markets Forensic Science Review 2013-03-01 Vol 25 (7-26) Bretteville-Jensen et al
Identification and analytical properties of new synthetic cannabimimetics bearing 2,2,3,3-tetramethylcyclopropanecarbonyl moiety Forensic Science International 2013-03-10 Vol 226 (62-73) Vadim Shevyrin et al
Spice, bath salts, and the U.S. military: the emergence of synthetic cannabinoid receptor agonists and cathinones in the U.S. Armed Forces. 2012-09-01 Loeffler G, Hurst D, Penn A, Yung K
Synthetic cannabinoid and marijuana exposures reported to poison centers Hum Exp Toxicol 2012-10-31 (1006-1011) MB Forrester et al
Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC–MS, NMR analysis and a flash chromato Forensic Science International 2012-07-12 Vol 220 (e17-e22) Bjoern Moosmann et al
Cannabinoid chemistry: an overview Cannabinoids as Therapeutics 2005-01-01 (23-46) Lumír O. Hanuš and Raphael Mechoulam
Identification and Quantitation of Two Cannabimimetic Phenylacetylindoles JWH-251 and JWH-250, and Four Cannabimimetic Naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073... Forensic Toxicol. 2011-11-05 Vol 29 Uchiyama et al.
Use of High-Resolution Accurate Mass Spectrometry to Detect Reported and Previously Unreported Cannabinomimetics in J. Anal. Toxicol. 2010-06-00 Vol 34 Hudson et al.
Cannabinoidmimetika: Massenspektren und IR-ATR-Spektren neuer Verbindungen aus den Jahren 2009/2010 (German) Toxichem Krimtech 2011-00-00 Vol 78(1) Kneisel et al.
Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles For. Toxicology 2011-01-01 Vol 29 Nahoko Uchiyama et. al.
Identification of Synthetic Cannabinoids in Herbal Incense Blends in the United States J. For. Sci. 2012-09-01 Vol 57 Barry K. Logan et al
Identification of a Novel Cannabimimetic Phenylacetylindole, Cannabipiperidiethanone, as a Designer Drug in a Herbal Product and Its Affinity for Cannabinoid CB1 and CB2 Receptors Chem. Pharm. Bull. 2011-01-01 Vol 59 (1203-1205) Nahoko Uchiyama, Ruri Kikura-Hanajiri, Yukihiro Goda
The emergence and analysis of synthetic cannabinoids Drug Testing and Analysis 2011-08-01 Vol 3 (466-478) Simon Hudson and John Ramsey
Database ID URL
SWGDRUG Mass Spectral Library 2286
SWGDRUG Monographs JWH-081 Monograph
European Project Response to Challenges in Forensic Drug Analyses JWH-081 Monograph
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