Structural, chemical and analytical data on controlled substances. The single reference site for forensic drug chemists. Click to login as forendex superuser Southern Association of Forensic Scientitsts
Search for a substance: Help
«MDMA»
CSA Names: MDMA
3,4-Methylenedioxymethamphetamine
CSA Location: Schedule I Section (d) Subsection (11) DEA code 7405
CSA History: 51 FR 36552 added (and renumbered subsequent entries) effective 13 Nov 1986
53 FR 2225 revoked effective 27 Jan 1988
53 FR 5156 added effective 23 Mar 1988
Names: 1-(1,3-Benzodioxol-5-yl)-N-methylpropan-2-amine (IUPAC)
Molecular formula: C11H15NO2
Nominal mass: 193
Average mass: 193.2423
Monoisotopic mass: 193.110279
CAS registry number: 42542-10-9
ChemSpider: 1556
PubChem: 1615
Wikipedia: Methylenedioxymethamphetamine
Erowid: MDMA
Drugs-Forum: MDMA
Bluelight: MDMA
Standard InChI: InChI=1S/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3
Standard InChI key: SHXWCVYOXRDMCX-UHFFFAOYSA-N
SMILES: CNC(Cc1ccc2c(c1)OCO2)C
Tags: USCSA,PiHKAL,phenethylamine
 
Property Value Remarks
Property Value Remarks
Location Type Remarks
MDMA base.pdf ATR IR Thermo Nicolet
MDMA HCl (dried).pdf ATR IR Thermo Nicolet
MDMA HCl.pdf ATR IR Thermo Nicolet
MDMA phosphate.pdf ATR IR Thermo Nicolet
MDMA sulfate.pdf ATR IR Thermo Nicolet
3,4-Methylenedioxymethamphetamine (NIST).pdf EI MS Used with the permission of NIST Mass Spectrometry Data Center Collection (C) 2008 copyright by the U.S. Secretary of Commerce on behalf of the United States of America. All rights reserved.
10979-0430048-GCMS.pdf EI MS methylene homolog
mdma ms.pdf EI MS Agilent MSD
MDMA.pdf EI MS UV FTIR Used with permission of CND Analytical. From "Analytical Profiles of the Hallucinogens"
3,4-MDMA.bmp GC IRD Used with Permission of Oklahoma State Bureau of Investigation, Forensic Science Center, Controlled Substances Laboratory.
MDMA (free base)-raman.pdf RAMAN GBI DOFS
MDMA HCl-raman.pdf RAMAN GBI DOFS
Vendor ID URL
Cayman Chemical 10979 (methylene homolog) http://www.caymanchem.com/app/template/Product.vm/catalog/10979
Cayman Chemical 11128 (3,4-dimethoxymethamphetamine) http://www.caymanchem.com/app/template/Product.vm/catalog/11128
Cerilliant NMID792 http://www.cerilliant.com/shoponline/Item_Details.aspx?itemno=86667b88-2d6a-49c3-9b30-d60eb989f15b
Cerilliant M-013 http://www.cerilliant.com/shoponline/Item_Details.aspx?itemno=fd2361ff-3670-4ede-9860-318cc3a16cfb
Grace Davison (Alltech) 01409 https://grace.com/pharma-and-biotech/en-us/Pages/Drug-Standards.aspx
Lipomed MDM-94-HC http://www.lipomed.com/index.php?eid=105§ion=mediadir&cmd=detail
Sigma Aldrich M6403 http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=M6403|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC
Sigma Aldrich M139 http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=M139|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC
THC Pharm THC-1347 https://biochem.thc-pharm.de/product_info.php?cPath=10&products_id=142
Tocris Bioscience 3027 http://www.tocris.com/dispprod.php?ItemId=190086&Controlled
Toronto Research Chemicals M303985 http://www.trc-canada.com/detail.php?CatNum=M303985
Title Publication Date Vol. Iss. Page(s) Remarks
PiHKAL • info Isomer Design
ANALYSIS OF METHOXY MDA DERIVATIVES SYNTHESIZED FROM NUTMEG OIL AND 3-METHOXY-4,5-METHYLENEDOXYBENZALDEHYDE Microgram Bulletin 1995-11-00 Vol 28 (11) Clark et al.
Methyl 3-[3′,4′-(methylenedioxy)phenyl]-2-methyl glycidate: An Ecstasy Precursor Seized in Sydney, Australia Journal of Forensic Sciences 2007-07-00 Vol 52 (4) Michael Collins Ph.D. et al
A Review of Recent Advances in Impurity Profiling of Illicit MDMA Samples Journal of Forensic Sciences 2007-11-00 Vol 52 (6) Ruth J. H. Waddell-Smith Ph.D.
Thin Layer Chromatography/Fluorescence Detection of 3,4-Methylenedioxy-Methamphetamine and Related Compounds Journal of Forensic Sciences 2008-11-00 Vol 53 (6) Noriyuki Kato B.Pharm. et al
N-Cyanomethyl-N-Methyl-1-(3′,4′-methylenedioxyphenyl)-2-propylamine: An MDMA Manufacturing By-Product Journal of Forensic Sciences 2008-09-00 Vol 53 (5) Helen Salouros B.Sc. et al
"DESIGNER DRUGS" IN THE ITALIAN CLANDESTINE MARKET: SITUATION AND NEW ANALYTICAL PROBLEMS Microgram Bulletin 1994-01-00 Vol 27 (1) Onelio Morselli et al.
Profiling of Ecstasy Tablets Seized in Japan Microgram Journal 2003-12-00 Vol 1 (3-4) Yukiko Makino, Shingo Kurobane, Kazuyoshi Miyasaka, and Kenichi Nagano
Selected Intelligence Brief ECSTASY AND CLUB DRUG TRAFFICKING IN THE PACIFIC NORTHWEST Microgram Bulletin 2004-01-00 Vol 37 (1)
MDMA (Ecstasy) (Law enforcement restricted publication) Microgram Bulletin 2002-06-00 Vol 35 (6) No analytical data
A NORMAL PHASE HPLC METHOD FOR THE QUANTITATION OF MDMA IN ILLICIT ECTASY TABLETS (Law enforcement restricted publication) Microgram Bulletin 2001-09-00 Vol 34 (9) KB Chan
LOGO AND HEADSPACE COMPARISON FOR SOURCE DETERMINATION OF ECSTASY TABLETS (Law enforcement restricted publication) Microgram Bulletin 2001-09-00 Vol 34 (9) Doan-Trang T. Vu
A PURITY SURVEY OF ECSTASY TABLETS IN CENTRAL FLORIDA DURING THE PERIOD DECEMBER 2000 TO MARCH 2001 (Law enforcement restricted publication) Microgram Bulletin 2001-10-00 Vol 34 (10) Orlando Ramos and Deborah K. Hahn
MDMA, MDEA, and & MBDB Tablets Seen in the US (Law enforcement restricted publication) Microgram Bulletin 2000-06-00 Vol 33 (6) Edward Sykes
The Separation and Identification of 3,4-Methylenedioxyamphetamine Derivatives (MDA, MDMA, MDEA, and MBDB) in Tablets (Law enforcement restricted publication) Microgram Bulletin 1999-01-00 Vol 32 (1) Nissim et al.
IDENTIFICATION OF THE PHOSPHATE SALT OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE ((Law enforcement restricted publication) Microgram Bulletin 1999-04-00 Vol 32 (4) John S. Chappell
HYDRATION POLYMORPHISM OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE HYDROCHLORIDE (Law enforcement restricted publication) Microgram Bulletin 1999-05-00 Vol 32 (5) John Chappell and Marsha Lee
METHODS OF DIFFERENTIATION FOR REGIOISOMERIC 2,3 AND 3,4-METHYLENEDIOXYPHENALKYLAMINES BY LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY (Law enforcement restricted publication) Microgram Bulletin 1998-09-00 Vol 31 (9) Clark et al.
THE ANALYSIS OF ECSTASY (MDMA ANALOGS AND HOMOLOGS) USING AN FT/IR SPECTROPHOTOMETER WITH MICROSCOPE ATTACHMENT (Law enforcement restricted publication) Microgram Bulletin 1998-12-00 Vol 31 (12) John Fox
ANALYTICAL PROPERTIES OF N-HYDROXY-3,4-METHYLENEDIOXYMETHAMPHETAMINE ("FLEA"), A POTENTIAL NEW STREET DRUG (Law enforcement restricted publication) Microgram Bulletin 1996-01-00 Vol 29 (1) Noggle et al.
GC-MS AND LIQUID CHROMATOGRAPHIC ANALYSIS OFAMPHETAMINE AND AMPHETAMINE-TYPE PRODUCTS FORMED IN THE REACTION OFARYLPROPENES WITH ACETONITRILE AND SULFURIC ACID (Law Enforcement Restricted Publication) Microgram Bulletin 1995-01-00 Vol 28 (1) F.T. Noggle et al.
Identification of Clandestinely Produced Methelenedioxy-isoquinolines Microgram Bulletin 1995-02-00 Vol 28 (2) Donald R. Robak
IDENTIFICATION OF 1-(3,4-METHYLENEDIOXYPHENYL)-2-BUTANAMINES RELATED TO MDMA (Law Enforcement Restricted Publication) Microgram Bulletin 1995-05-00 Vol 28 (5) C. Randall Clark et al.
ECSTASY TABLETS CONTAINING MDMA AND 3,4-METHYLENEDIOXY-DIMETHYLAMPHETAMINE (MDDMA) IN JOHNSON COUNTY, KANSAS Microgram Bulletin 2006-06-00 Vol 39 (6) Mass Spectra of MDMA and MDDMA
Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in the Netherlands Sci. and Justice J. 2006-07-01 Vol 46 (135-152) M.M. van Deursen, E.R.A. Lock and A.J. Poortman-van der Meer
The Variability of Ecstasy Tablets Composition in Brazil J. For. Sci. 2015-01-01 Vol 60 (147-151) Loraine R. Togni et al
GC–MS studies on acylated derivatives of 3-methoxy-4-methyl- and 4-methoxy-3-methyl-phenethylamines: Regioisomers related to 3,4-MDMA. DOI: 10.1016/j.forsciint.2008.02.002. For. Sci. Int 2008-06-01 Vol 178 (1) Awad, Belal, DeRuiter, Clark
Chromatographic and Mass Spectral Studies on Methoxy Methyl Methamphetamines Related to 3,4-Methylenedioxymethamphetamine. DOI: 10.1093/chromsci/45.8.466 Journal of Chrom. Sci. 2007-09-01 Vol 45 (8) Awad, DeRuiter, Clark
GC–MS Analysis of Acylated Derivatives of a Series of Side Chain Regioisomers of 2-Methoxy-4-Methyl-Phenethylamines. DOI: 10.1093/chromsci/46.5.375 Journal of Chrom. Sci. 2008-05-01 Vol 46 (5) Awad, DeRuiter, Clark
GC-MS Analysis of Acylated Derivatives of the Side-Chain Regioisomers of 4-Methoxy-3-Methyl-Phenethylamines Related to Methylenedioxymethamphetamine. DOI:10.1093/chromsci/45.8.477 Journal of Chrom. Sci. 2007-09-01 Vol 45 Awad, Clark, DeRuiter
Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines b10.1002/1096-9888(200006)y gas chromatography/tandem mass spectrometry. DOI: Journal of Mass Spectrometry 2000-06-01 Vol 35 (6) Borth, Hansel, Rosner, Junge
Gas Chromatographic Optimization Studies on the Side Chain and Ring Regioisomers of Methylenedioxymethamphetamine. DOI:10.1093/chromsci/42.6.293 Journal of Chrom. Sci. 2004-07-01 Vol 42 Aalberg, Sippola, DeRuiter, Clark
Chromatographic and Mass Spectral Studies on Isobaric and Isomeric Substances Related to 3,4-Methylenedioxymethamphetamine. DOI:10.1093/chromsci/42.9.464 Journal of Chrom. Sci. 2004-10-01 Vol 42 Aalberg, Clark, DeRuiter
GC–IRD methods for the identification of some tertiary amines related to MDMA. DOI:10.1016/j.forsciint.2010.02.022 For. Sci. Int. 2010-06-01 Vol 199 Maher, Awad, DeRuiter, Clark
Chromatographic and Mass Spectral Studies on Methoxymethcathinones Related to 3,4-Methylenedioxymethamphetamine. DOI:10.1093/chromsci/44.3.155 Journal of Chrom. Sci. 2006-03-01 Vol 44 Awad, Clark, DeRuiter
GC–IRD methods for the identification of some tertiary amines related to MDMA. DOI:10.1016/j.forsciint.2010.02.022 For. Sci. Int. 2010-06-01 Vol 199 Maher, Awad, DeRuiter, Clark
Liquid Chromatographic and Spectral Methods for the Differentiation of 3,4-Methylenedioxymethamphetamine (MDMA) from Regioisomeric Phenethylamines. DOI:10.1080/01483919108049662 Journal of Liquid Chrom. 1991-01-01 Vol 14 (10) Noggle, Clark, DeRuiter
GC–MS and GC–IRD Studies on the Ring Isomers of N-Methyl-2-Methoxyphenyl-3-Butanamines (MPBA) Related to 3,4-MDMA. DOI:10.1093/chromsci/49.5.345 Journal of Chrom. Sci. 2011-05-01 Vol 49 Awad, Maher, DeRuiter, Clark
The Identification of 3,4-MDMA from Its Mass Equivalent Isomers and Isobaric Substances Using Fast LC–ESI-MS–MS. DOI:10.1093/chromsci/43.2.92 Journal of Chrom. Sci. 2005-02-01 Vol 43 Pihlainen, Aalberg, Tepponen, Clark, Kostiainen
GC–IRD methods for the identification of isomeric ethoxyphenethylamines and methoxymethcathinones. DOI:10.1016/j.forsciint.2008.12.003 For. Sci. Int. 2009-01-01 Vol 184 Balel, Awad, DeRuiter, Clark
Synthesis and Analytical Profiles for Regioisomeric and Isobaric Amines Related to MDMA, MDEA and MBDB: Differentiation of Drug and Non-Drug Substances of Mass Spectral Equivalence 2011-10-01 C. Randall Clark
A re-examination of the mono-methoxy positional ring isomers of amphetamine, methamphetamine and phenyl-2-propanone. DOI:10.1016/S0379-0738(00)00425-4 For. Sci. Int. 2001-06-15 Vol 119 (2) Terry A. Del Cason
Separation and Identification of Drug Enantiomers via N-TFA-(S)-Prolyl Chloride Derivatization Journal of CLIC 1992-01-00 Vol 2 (1) Law Enforcement Restricted
Differentiation of Side Chain Isomers of Ring-Substituted Amphetamines Using Gas Chromatography/Infrared/Mass Spectrometry (GC/IR/MS). DOI:10.1520/JFS13259J Journal of Forensic Sciences 1991-03-01 Vol 37 (2) WH Soine et al
Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS) Drug Testing and Analysis 2009-07-01 Vol 1 (7) Sigalit Gura, Patricia Guerra-Diaz, Hanh Lai and José R. Almirall
Impact of reaction parameters on the chemical profile of 3,4-methylenedioxymethamphetamine synthesized via reductive amination: For. Sci. Int. 2013-12-10 Vol 233 M. Schäffer, S. Dieckmann, M. Pütz, T. Kohles, U. Pyell, R. Zimmermann
Application of dispersive liquid–liquid microextraction and CE with UV detection for the chiral separation and determination of the multiple illicit drugs on forensic samples For. Sci. Int. 2011-06-15 Vol 209 Liang Meng, Bin Wang, Feng Luo, Guijun Shen, Zhengqiao Wang, Ming Guo
Screening for illicit drugs on Euro banknotes by LC–MS/MS For. Sci. Int. 2011-03-20 Vol 206 Kurt Wimmer, Serge Schneider
Reliability of ion mobility spectrometry for qualitative analysis of complex, multicomponent illicit drug samples For. Sci. Int. 2011-03-20 Vol 206 Jennifer R. Verkouteren, Jessica L. Staymates
The profiling of MDMA tablets: A study of the combination of physical characteristics and organic impurities as sources of information For. Sci. Int. 2009-05-30 Vol 187 Quentin Milliet, Céline Weyermann, Pierre Esseiva
Optimization of HS-SPME/GC–MS analysis and its use in the profiling of illicit ecstasy tablets (Part 1) For. Sci. Int. 2009-05-30 Vol 187 Federica Bonadio, Pierre Margot, Olivier Delémont, Pierre Esseiva
Headspace solid-phase microextraction (HS-SPME) and liquid–liquid extraction (LLE): Comparison of the performance in classification of ecstasy tablets (Part 2) For. Sci. Int. 2008-11-20 Vol 182 Federica Bonadio, Pierre Margot, Olivier Delémont, Pierre Esseiva
Elemental analysis of 3,4-methylenedioxymethamphetamine (MDMA): A tool to determine the synthesis method and trace links For. Sci. Int. 2007-09-13 Vol 171 C. Koper et al
Impurity profiling of ecstasy tablets seized in Hong Kong by gas chromatography–mass spectrometry For. Sci. Int. 2006-10-16 Vol 162 Jack Yuk Ki Cheng, Man Fai Chan, Tai Wai Chan, Mei Yuen Hung
A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes For. Sci. Int. 2005-12-20 Vol 155 P. Gimeno, F. Besacier, M. Bottex, L. Dujourdy, H. Chaudron-Thozet
Determination of synthesis method of ecstasy based on the basic impurities For. Sci. Int. 2005-09-10 Vol 152 M. Świst, J. Wilamowski, A. Parczewski
Rapid and simple method for direct determination of several amphetamines in seized tablets by GC–FID For. Sci. Int. 2005-09-10 Vol 152 Blagoj Mitrevski, Zoran Zdravkovski
Underground pill testing, down under For. Sci. Int. 2005-07-16 Vol 151 Andrew M. Camilleri, David Caldicott
Determination of synthesis route of 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P) based on impurity profiles of MDMA For. Sci. Int. 2005-05-10 Vol 149 M. Świst, J. Wilamowski, D. Zuba, J. Kochana, A. Parczewski
Analysis of ecstasy tablets: comparison of reflectance and transmittance near infrared spectroscopy For. Sci. Int. 2003-07-08 Vol 134 Ralph Carsten Schneider, Karl-Artur Kovar
Optimization of extraction parameters for the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets For. Sci. Int. 2003-04-08 Vol 132 Pascal Gimeno, Fabrice Besacier, Huguette Chaudron-Thozet
A contribution to the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets For. Sci. Int. 2002-06-25 Vol 127 Pascal Gimeno et al
Screening experiments of ecstasy street samples using near infrared spectroscopy For. Sci. Int. 1999-12-20 Vol 106 Nicole Sondermann, Karl-Artur Kovar
Identification of ecstasy in complex matrices using near-infrared spectroscopy For. Sci. Int. 1999-06-28 Vol 102 Nicole Sondermann,Karl-Artur Kovar
Identification of 3,4-methylenedioxyamphetamine analogs encountered in clandestine tablets For. Sci. Int. 1998-03-02 Vol 91 Carmelo Furnari et al
A study of the precursors, intermediates and reaction by-products in the synthesis of 3,4-methylenedioxymethylamphetamine and its application to forensic drug analysis For. Sci. Int. 1993-08-01 Vol 60 R.J. Renton, J.S. Cowie, M.C.H. Oon
Clandestine manufacture of 3,4-methylenedioxymethylamphetamine (MDMA) by low pressure reductive amination. A mass spectrometric study of some reaction mixtures For. Sci. Int. 1990-03-01 Vol 45 Anthonie M.A. Verweij
Analysis of Ecstasy Tablets Using Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection J. For. Sci. 2014-11-01 Vol 59 Suely K. S. S. Porto et al
Effect of Extraction Procedure and Gas Chromatography Temperature Program on Discrimination of MDMA Exhibits J. For. Sci. 2014-03-01 Vol 59 Karlie M. McManaman and Ruth Waddell Smith
Objective Color Classification of Ecstasy Tablets by Hyperspectral Imaging J. For. Sci. 2013-07-01 Vol 58 Gerda Edelman, Martin Lopatka and Maurice Aalders
Comparative Analysis of the Chemical Profiles of 3,4-Methylenedioxymethamphetamine Based on Comprehensive Two-Dimensional Gas Chromatography–Time-of-Flight Mass Spectrometry (GC × GC-TOFMS)* J. For. Sci. 2012-09-01 Vol 57 Marion Schäffer et al
N-Cyanomethyl-N-Methyl-1-(3′,4′-methylenedioxyphenyl)-2-propylamine: An MDMA Manufacturing By-Product J. For. Sci. 2008-09-01 Vol 53 Helen Salouros et al
Validation of an HPLC Method for Quantitation of MDMA in Tablets J. Chrom. Sci. 2005-09-01 Vol 43 (8) I.B. Müller and C.N. Windberg
GC-FID optimization and validation for determination of 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine and methamphetamine in ecstasy tablets J. Analytical Chem. 2010-09-01 Vol 65 (9) A. Phonchai, B. Janchawee, S. Prutipanlai, S. Thainchaiwattana
Gas chromatographic/mass spectrometric assay for profiling the enantiomers of 3,4-methylenedioxymethamphetamine and its chiral metabolites using positive chemical ionization ion trap mass spectrometry Journal of Mass Spectrometry 1997-11-01 Vol 32 (1236-1246) D. de Boer et al
Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material Egyptian J. For. Sci. 2014-09-01 Vol 4 (90-99) Yacine Boumrah et al
Chemical profiling of ecstasy recovered from around Jakarta by High Performance Thin Layer Chromatography (HPTLC)-densitometry Egyptian J. For. Sci. 2012-09-01 Vol 2 (97-104) I Made Agus Gelgel Wirasuta
Determination of 3,4-methylenedioxymethamphetamine (MDMA) in Confiscated Tablets by High-Performance Liquid Chromatography (HPLC) with Diode Array Detector Journal of Forensic Research 2010-12-01 Vol 1 Natalia Biziak de Figueiredo et al
Substance name
Methylone
Please send us your comments, questions or suggestions · Collaborate with colleagues at Forendex Forum
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License Updated 3 March 2017